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The main treatments for NGU are the antibiotics azithromycin and doxycycline. Alternative antibiotics are erythromycin and ofloxacin. A woman who is pregnant, or thinks she might be, should tell her doctor. This will ensure that a medicine will be used that will not harm the baby. Take all medications, even if you start to feel better before you finish the bottle. Inform all partners. Abstain from sex until all partners are treated. Return for evaluation by a health care provider if symptoms persist or if symptoms recur after taking all the prescribed medicine.

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